A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Celiac Disease Panel, Infant

Message


Order CELI for patients less than 4 years old.  Order CELP for patients greater than 4 years old.




Test Code
LAB6068


Quest Code
15981


Alias/See Also
CELI 


CPT Codes
83516 (x2), 82784

Includes
Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)
Gliadin (Deamidated) Antibody (IgA)

If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86231).
If the Endomysial Antibody Screen (IgA) is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).

If Immunoglobulin A is less than the lower limit of the reference range, based on age, then Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364).


Preferred Specimen
5 mL serum

Note: Specimens from children less than 4 years of age (i.e., less than 48 months) are appropriate for this test. The test for people 4 years of age and older is the Celiac Disease Comprehensive Panel (test code 19955).


Minimum Volume
1.1 mL


Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic


Methodology
See individual tests

Setup Schedule
P.M. Sets up 5 days a week.


Reference Range
(tTG) Antibody, (IgA)
<15 U/mL No antibody detected
≥15 U/mL Antibody detected

Gliadin (Deamidated) Antibody (IgA)
<15 Units Antibody not detected
≥15 Units Antibody detected

IgA, Serum
Cord Blood 1-3 mg/dL
1-28 days 2-40 mg/dL
1-3 months 3-40 mg/dL
4-6 months 7-47 mg/dL
7-11 months 12-53 mg/dL
1 year 20-73 mg/dL
2 years 20-99 mg/dL
3-5 years 22-140 mg/dL
6-8 years 31-180 mg/dL
9-11 years 33-200 mg/dL
12-16 years 36-220 mg/dL
17-60 years 47-310 mg/dL
≥61 years 70-320 mg/dL


Clinical Significance
Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.
Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.


Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.