Adenosine Deaminase, Pleural Fluid

Test Code

LAB6237

Quest Code

17696

Alias/See Also

ADEAF, ADA Pleural Fluid

CPT Codes
84311

Preferred Specimen

0.5 mL pleural fluid in a sterile screw cap container

Minimum Volume

0.1 mL

Transport Temperature

Frozen

Specimen Stability

Room temperature: 24 hours
Refrigerated: 72 hours
Frozen: 6 months

Methodology
Kinetic Spectrophotometric (KS)

FDA Status
This test was performed using a kit that has ot been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.

Setup Schedule

Set up Mon-Sat; Report available: 1-2 days

Reference Range

Adenosine Deaminase, Pleural Fluid	<9.2 U/L
Tuberculosis	mean 92.1 U/L
Metastatic malignancies	mean 23.3 U/L
Mesotheliomas	mean 34.9 U/L
Pulmonary embolism	mean 23.8 U/L
Lymphoma	mean 64.3 U/L

Clinical Significance

An elevated level of adenosine deaminase (AD) in human serum, plasma or select body fluids is used as a surrogate marker for inflammation or infectious disease. In CSF, pleural effusions, and pericardial fluid in particular, elevated AD activity has been shown to be associated with tubercular lesions. Additional disease states that may result in elevated AD activity include liver cirrhosis, liver fibrosis, certain malignancies (e. g. lymphoma), viral hepatitis, and autoimmune diseases (e. g. SLE, rheumatoid arthritis).

Performing Laboratory
Quest Diagnostics Chantilly Nichols Institute
14225 Newbrook Dr.
Chantilly, VA 20151-2228

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.