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Complement Component C3c and C4c
Test CodeLAB6318
Quest Code
5704
Alias/See Also
C3C4C; C3C4
CPT Codes
86160 (x2)
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 4 days
Frozen: 21 days
Refrigerated: 4 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature
Methodology
Immunoturbidimetric
Setup Schedule
Set up: Sun-Fri; Report available: 2-4 days
Reference Range
See individual tests
Clinical Significance
Decreased concentrations of both C3 and C4 suggest activation of the classical pathway, whereas decreased concentration of just C3 suggests activation of the alternative pathway. Both complement factors may be used to monitor activity of patients with systemic lupus erythematosus (SLE) and immune complex-induced vasculitis.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130