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Vitamin B12
Test CodeLAB67
Alias/See Also
Cyanocobalimin; VITB12; VB12; B12
CPT Codes
82607
Instructions
Routine venipuncture. 5ml Red/gold top serum separator tube.
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis; nonserum specimen; failure to follow proper collection or storage procedures
Methodology
Competitive binding assay: The amount of HRP conjugate bound is indirectly proportional to the concentration of vitamin B12 present.
Setup Schedule
Within 24 hours
Report Available
Daily
Reference Range
239-931 pg/mL
Clinical Significance
"Vitamin B12 and folate are critical to normal DNA synthesis, which in turn affects erythrocyte maturation. Clinical and laboratory findings for B12 deficiency include neurological abnormalities, decreased serum B12 levels, and increased excretion of methylmalonic acid. The impaired DNA synthesis associated with B12 deficiency causes macrocytic anemias. These anemias are characterized by abnormal maturation of erythrocyte precursors in the bone marrow which results in the presence of megaloblasts and decreased red cell survival.
Pernicious anemia is a macrocytic anemia caused by B12 deficiency that is due to the lack of intrinsic factor. Low B12 intake, gastrectomy, diseases of the small intestine, and malabsorption can also cause vitamin B12 deficiency."
Pernicious anemia is a macrocytic anemia caused by B12 deficiency that is due to the lack of intrinsic factor. Low B12 intake, gastrectomy, diseases of the small intestine, and malabsorption can also cause vitamin B12 deficiency."
