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Vancomycin Trough
Test CodeLAB39
Alias/See Also
VANT
Preferred Specimen
"Routine venipuncture. Collect one 5 ml red/gold top serum separator tube."
Instructions
"Trough drug monitoring should begin after steady state is achieved and samples should be collected within 30 minutes of the next dose."
Specimen Stability
Room Temp 2 hrs, Refrigerated 3 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimen collected at inappropriate time.
Methodology
Two point rate: The assay is based on competition between VANC in the sample and vancomycin labeled with G6P-DH for antibody binding sites.
Setup Schedule
Daily/STAT
Report Available
within 1 hour
Reference Range
"5.0-10.0 ug/ml
Critical High Value: >20.0 ug/ml"
Critical High Value: >20.0 ug/ml"
Clinical Significance
Vancomycin is used in the treatment of serious or severe infections caused by gram-positive organisms resistant to penicillins,cephalosporins, or other antimicrobial agents. It is also used in thetreatment of antibiotic-associated pseudomembranous colitis produced byClostridium difficile. The risk of ototoxicity and nephrotoxicity isincreased in patients with impaired renal function, and in patientsreceiving concurrent aminoglycoside treatment. Serum or plasmavancomycin measurements are used in the diagnosis and treatment ofvancomycin overdose and in monitoring levels of vancomycin to ensureappropriate therapy.
