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Vancomycin Peak
Test CodeLAB41
Alias/See Also
VANP
Preferred Specimen
" Routine venipuncture. Collect one 5 ml red/gold top serum separator tube. "
Instructions
" When peak levels are being measured, samples should be drawn 2 hours after an infusion. "
Specimen Stability
Room Temp 2 hrs, Refrigerated 3 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimen collected at inappropriate time.
Methodology
"Two point rate: The assay is based on competition between VANC in the sample and vancomycin labeled with G6P-DH for antibody binding sites."
Setup Schedule
"
Daily/STAT
"
Daily/STAT
"
Report Available
within 1 hour
Reference Range
30.0-40.0 ug/ml
Clinical Significance
"Vancomycin is used in the treatment of serious or severe infections
caused by gram-positive organisms resistant to penicillins,
cephalosporins, or other antimicrobial agents. It is also used in the
treatment of antibiotic-associated pseudomembranous colitis produced by
Clostridium difficile. The risk of ototoxicity and nephrotoxicity is
increased in patients with impaired renal function, and in patients
receiving concurrent aminoglycoside treatment. Serum or plasma
vancomycin measurements are used in the diagnosis and treatment of
vancomycin overdose and in monitoring levels of vancomycin to ensure
appropriate therapy.
"
caused by gram-positive organisms resistant to penicillins,
cephalosporins, or other antimicrobial agents. It is also used in the
treatment of antibiotic-associated pseudomembranous colitis produced by
Clostridium difficile. The risk of ototoxicity and nephrotoxicity is
increased in patients with impaired renal function, and in patients
receiving concurrent aminoglycoside treatment. Serum or plasma
vancomycin measurements are used in the diagnosis and treatment of
vancomycin overdose and in monitoring levels of vancomycin to ensure
appropriate therapy.
"
