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PTT Mixing Study
Test CodeLAB2312
CPT Codes
85730x2, 85732
Includes
Partial thromboplastin time (Patient Plasma) in seconds for 1 hour or 1 hour and 2 hour incubations, Partial thromboplastin time (Patient Plasma plus Normal Plasma) in seconds
Instructions
"Routine venipuncture; Collect one 2.7ml Blue top (sodium citrate) 90% of tube must be filled. do not use syringe for collection."
Indicate incubation time (1 hour or 2 hour) at order entry.
Indicate incubation time (1 hour or 2 hour) at order entry.
Specimen Stability
Room temperature, stable 12 hours.
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Tube <90% full; visible hemolysis; clotted specimen; improperly labeled specimen
Reference Range
"APTT: 24.1-37.4 seconds ; Critical: Greater than 45.1 Seconds
Normal Cal Plasma: 24.0-36.0 seconds
1:1 Patient Plasma/Normal Cal Plasma: See interpretive data"
Normal Cal Plasma: 24.0-36.0 seconds
1:1 Patient Plasma/Normal Cal Plasma: See interpretive data"
Clinical Significance
"A correction of the patient PTT with the addition of normal plasma to within normal range is indicative of a factor VIII, IX, X, XI or XIII deficiency. A patient with a factor deficiency may have a bleeding tendancy. A partial correction of the patient PTT (within <5 sec), no correction or a longer PTT result is indicative of a lupus like inhibitor. A patient with an inhibitor can be at risk for thrombotic episodes. The presence of anticoagulant drugs such as heparin or direct thrombin inhibitors cannot be excluded."
Additional Information
Guidelines for Hypercoagulable State Testing
