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PT Mixing Study
Test CodeLAB2311
Includes
Prothrombin time in seconds (Patient Plasma); Prothrombin time in seconds (Patient Plasma mixed witih Normal Plasma);international normalized ratio (INR),
Instructions
"Routine venipuncture;
do not use syringe for collectionBlue top (sodium citrate) tube2.7 mL; 90% of tube must be filled."
do not use syringe for collectionBlue top (sodium citrate) tube2.7 mL; 90% of tube must be filled."
Transport Temperature
Room temperature
Specimen Stability
Room temperature, stable 12 hours.
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Tube <90% full; visible hemolysis; clotted specimen; improperly labeled specimen
blood collected with anticoagulants such as EDTA, heparin, oxalate, or citrate"
blood collected with anticoagulants such as EDTA, heparin, oxalate, or citrate"
Methodology
Turbidimetric clot detection (optical density)
Setup Schedule
Daily
Reference Range
"Prothromibin Time (PT): 11.6-14.3 sec
INR: 0.83 - 1.21 ;
Critical Level: Less than 0.19 or Greater than 5.01
Therapeutic ranges:
INR: 2.0-3.0: prophylaxis for venous thromboembolism, and treatment for deep vein thrombosis and pulmonary embolism.
INR: 2.5-3.5: mechanical heart valves, recurrent embolism."
INR: 0.83 - 1.21 ;
Critical Level: Less than 0.19 or Greater than 5.01
Therapeutic ranges:
INR: 2.0-3.0: prophylaxis for venous thromboembolism, and treatment for deep vein thrombosis and pulmonary embolism.
INR: 2.5-3.5: mechanical heart valves, recurrent embolism."
Clinical Significance
A correction of the patient PT with the addition of normal
plasma to within normal range is indicative of a factor
II, V, VII, or X deficiency. A patient with a factor
deficiency may have a bleeding tendancy.
A partial correction of the patient PT (within <5 sec), no
correction or a longer PT result is indicative of an inhibitor.
A patient with an inhibitor can be at risk for thrombotic
episodes.
The presence of anticoagulant drugs such as heparin or direct
thrombin inhibitors cannot be excluded.
plasma to within normal range is indicative of a factor
II, V, VII, or X deficiency. A patient with a factor
deficiency may have a bleeding tendancy.
A partial correction of the patient PT (within <5 sec), no
correction or a longer PT result is indicative of an inhibitor.
A patient with an inhibitor can be at risk for thrombotic
episodes.
The presence of anticoagulant drugs such as heparin or direct
thrombin inhibitors cannot be excluded.
