PSA Free and Total

Message

This electrochemiluminescence immunoassay is performed on a Roche Cobas e411. Different testing methods should not be used interchangeably, particularly in serial monitoring, as results can vary due to differences in assay methods or reagent specificity.

Test Code

LAB171

Alias/See Also

PSAFT

Includes

"Free PSA
Prostate Specific Antigen"

Preferred Specimen

SST serum

Instructions

One yellow top SST tube

Specimen Stability

5 days refrigerated

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Plasma specimens are not acceptable.

Methodology
Electrochemiluminescence immunoassay

Setup Schedule

Daily

Limitations

Biotin >80ng/mL can lead to falsely depressed total PSA

Biotin (doses >5mg/day) – wait at least 8 hours following the last biotin dose

Flutamide at therapeutic daily doses can lead to slightly depressed free PSA

Reference Range

Total PSA <4.0 ng/mL
Free PSA none established

Additional Information
NCD-ABN_PSA

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.