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P2Y12 Platelet Function
Test CodeLAB2313
Alias/See Also
Ticagrelor Platelet Function Test
Ticlopidine (Ticlid) Platelet Function Test
Plavix Platelet Function Test
Verify Now P2Y12
P2Y12 Platelet Function Test
Clopidogrel (Plavix) Platelet Function Test
Thienopyridine Platelet Function Test
Prasurgrel Platelet Function Test
Brilinta (Ticagrelor)
Ticlopidine (Ticlid) Platelet Function Test
Plavix Platelet Function Test
Verify Now P2Y12
P2Y12 Platelet Function Test
Clopidogrel (Plavix) Platelet Function Test
Thienopyridine Platelet Function Test
Prasurgrel Platelet Function Test
Brilinta (Ticagrelor)
CPT Codes
85576
Preferred Specimen
2.7 mL blue top (citrate 3.2%) tube whole blood
Patient Preparation
Manufacturer recommended test timing based on therapy and dose:
Clopiogrel (Plavix(R)) 75 mg >= 7 days on maintenance
300 mg >= 8 hours post-bolus
600 mg >= 6 hours post-bolus
Prasugrel (Effent(r)) 5 mg >= 5 days on maintenance
10 mg >= 5 days on maintenance
60 mg >= 45 minutes post-bolus
Ticagretor (Brilinta(r)/Brilique(R)) 180 mg >= 2 hours post-bolus (Within 8 hours)
Minimum Volume
2mL
Instructions
Collect specimen in a 2.7 mL blue top (citrate 3.2%) tube using a 21 gauge or larger needle. Mix by inversion. Do not centrifuge. Whole blood specimen should arrive at lab within 3 hours of collection; transport at room temperature. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.
Special Handling
DO NOT SEND THROUGH PNEUMATIC TUBE SYSTEM.
Special Handling
DO NOT SEND THROUGH PNEUMATIC TUBE SYSTEM.
Transport Container
Primary Container.
Transport Temperature
Room Temp
Specimen Stability
Whole blood specimen should arrive at lab within 3 hours of collection.
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimens will be rejected if not properly filled, clotted, grossly hemolyzed, or contaminated with heparin, or sent through the pneumatic tube system.
Methodology
Whole Blood aggregometry (platelet inhibition) VerifyNow P2Y12 (PRU) assay
Setup Schedule
Daily, Stat as needed
Report Available
1-2 hours
Limitations
Test Limitations
Platelet counts less than 119K or more than 502K, and Hematocrit values less than 33% or greater than 52% can interfere with testing and valid results may not be obtained.
The P2Y12 Platelet Function assay is not intended for use with inherited platelet disorders such as von Willebrand Factor Deficiency, Glanzmann Thrombasthenia and Bernard-Soulier Syndrome.
Platelet counts less than 119K or more than 502K, and Hematocrit values less than 33% or greater than 52% can interfere with testing and valid results may not be obtained.
The P2Y12 Platelet Function assay is not intended for use with inherited platelet disorders such as von Willebrand Factor Deficiency, Glanzmann Thrombasthenia and Bernard-Soulier Syndrome.
Reference Range
180 - 376 PRU. Values less than 180 PRU may be evidence of a P2Y12 inhibitor effect.
Clinical Significance
To determine the degree of platelet inhibition from the use of P2Y12 inhibition drug therapies known as thienopyridines. These include Clopidogrel (Plavix), Prasugrel, Ticlopidine (Ticlid), and Ticagrelor.
Performing Laboratory
CHOMP Laboratory
