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N-Terminal Pro BNP

Test Code
LAB106


Alias/See Also
BNP; Brain Natriuretic Peptide, B-type 


CPT Codes
83880

Instructions
Routine venipuncture Collect one 4.5ml Light green top (lithium heparin) tube or one 5ml Red/gold top serum separator tube. Refrigerate within 8 hours

 


Transport Temperature
Refrigerated


Specimen Stability
Stable for 3 days refrigerated 


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Turbid or grossly hemolyzed specimen


Methodology
Immunometric:The amount of HRP conjugate bound is directly proportional to the concentration of NT-proBNP present.

Setup Schedule
Daily


Report Available
Daily STAT:1hr


Reference Range
0-300 pg/mL
 


Clinical Significance
The recommended cut points for symptomatic patients:
CHF unlikely                             
  • Age <50 years     0-300 pg/mL (98% NPV)       
  • Age 50-75 years   0-300 pg/mL (98% NPV)
  • Age >75 years     0-300 pg/mL (98% NPV)
CHF possible
  • Age <50 years     300-450 pg/mL      
  • Age 50-75 years   300-900 pg/mL
  • Age >75 years     300-1800 pg/mL
CHF likely
  • Age <50 years     >450 pg/mL(76% PPV)       
  • Age 50-75 years   >900 pg/mL (83% PPV)
  • Age >75 years     >1800 pg/mL (92% PPV)
COMMENT:  NPV is Negative Predictive Value, PPV is Positive Predictive Value.


Performing Laboratory
CH CHOMP HOSPITAL LAB (831-625-4811): CH CHEMISTRY


Additional Information
LCD-ABN_B-Type_NatriureticPeptide


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.