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LDH, Body Fluid
Test CodeLAB188
Alias/See Also
LDHFL
CPT Codes
83615
Instructions
"Collect minimum 1 mL of body fluid and place in plain evacuated serum separator tube or a sterile conatiner.
Indicate the specimen source.
Transport to the laboratory as soon as possible."
Indicate the specimen source.
Transport to the laboratory as soon as possible."
Specimen Stability
"Room Temp 2 days, Refrigerated and Frozen- Not acceptable
Handle and store specimens in closed containers"
Handle and store specimens in closed containers"
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Failure to follow collection and handling requirements.
Methodology
Multiple point rate:The oxidation of NADH, which is monitored by reflectance spectrophotometry, is used to measure LDH activity.
Setup Schedule
Daily
Report Available
Daily
Reference Range
None established, IU/L
Clinical Significance
Lactate dehydrogenase is an enzyme present in the cytosol of all human cells; it catalyzes the reversible reduction of pyruvateto lactate using NADH. Causes of high LDH include neoplastic states, hypoxic cardiorespiratory diseases, myocardial infarctions, hemolytic anemias, megaloblastic anemias, hepatic cirrhosis, renal infarction, trauma, muscle damage, muscular dystrophy, shock, and hypotension. In myocardial infarction cases, LDH begins to rise within about 12 hours after infarction and usually returns to normal after two to five days.
