CK Total and CKMB

Test Code

LAB63

Alias/See Also

CPKMB

CPT Codes
82550, 82553

Includes

CK-MB always includes CK

Instructions

Collect one 4.5ml light green top (heparin) tube or one 5ml Red/gold top serum separator tube,

Specimen Stability

Refrigerate, stable 8 hours; stable 4 hours at room temperature; stable 2-3 days if frozen.

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Insufficient quantity; gross hemolysis, lipemia, or icterus; failure to follow stability requirements

Methodology
"CPK: Multiple-point rate:The rate of change in reflection density is then converted to enzyme activity. CKMB: Immunometric:The amount of HRP conjugate bound is directly proportional to the concentration of CK-MB present."

Setup Schedule

Daily

Report Available

"Within 24 hours
STAT:1 hour"

Reference Range

"CKMB: 0.22-4.50 ng/mL
Total CPK:
Females: 30-135 U/L
Males: 55-170 U/L
Percent CKMB: 0.0-2.5 %"

Clinical Significance

After an acute MI (myocardial infarction) the CK-MB leaks into the circulation reflecting damage to the myocardium. CK-MB rises rapidly to peak levels within 12 hours, then declines to normal levels within 36-72 hours. Elevated CK-MB levels are also associated with skeletal muscle trauma but do not have the rise and fall characteristics of acute MI CK-MB levels.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.