A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
ACTH, Plasma
MessageMUST BE DRAWN AT MAIN LAB
Test Code
LAB511
Quest Code
211
Alias/See Also
ACTHM, ACTH
CPT Codes
82024
Preferred Specimen
1.5 mL plasma collected in EDTA (lavendar-
top) tube. Spun immediately and frozen.
top) tube. Spun immediately and frozen.
Patient Preparation
Draw specimens between 7AM and 10AM. If drawn during any other time, the reference ranges do not apply.
Minimum Volume
0.5 mL
Other Acceptable Specimens
PPT-potassium EDTA (white-top) tube
Instructions
Draw specimens between 7AM and 10AM.
If drawn during any other time, the reference ranges do not apply.
Centrifuge immediately and transfer the plasma to a plastic specimen transport container and Freeze immediately.
Do not thaw.
If drawn during any other time, the reference ranges do not apply.
Centrifuge immediately and transfer the plasma to a plastic specimen transport container and Freeze immediately.
Do not thaw.
Transport Temperature
Frozen
Specimen Stability
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received thawed • Received room temperature • Received refrigerated
Methodology
Immunoassay (IA)
Setup Schedule
A.M. Sets up 5 days a week.
Limitations
With patients receiving more than 5mg/day of biotin, a sample should be taken no sooner than eight hours after previous dose. Patients treated with monoclonal mouse antibodies may have inaccurate results. High titer of antibodies such as streptavidin and ruthenium may cause interference. Due to its correlation with cortisol levels, ACTH concentration is affected by stress. Any single measure may be within the reference range for patients with increased production (Cushing's disease) or minimal production of ACTH.
Reference Range
<3 Years | Not established |
3-17 Years | 9-57 pg/mL |
≥18 Years | 6-50 pg/mL |
Clinical Significance
Determination of ACTH is useful in differentiating between primary and secondary adrenocortical hypo- and hyperfunctional disorders: Addison's Disease, Cushing's Syndrome, Adrenal Carcinoma, Ectopic ACTH Syndrome, Nodular Hyperplasia.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130