Cardiolipin Antibodies (IgA, IgG, IgM)

Test Code

LAB464

Quest Code

7352

Alias/See Also

CARAB; CARLN; Antiphospholipid Antibodies

CPT Codes
86147 (x3)

Preferred Specimen

1 mL citrated plasma collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume

0.5 mL

Other Acceptable Specimens

Serum

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 5 days

Refrigerated: 14 days

Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic

Methodology
Immunoassay (IA)

Setup Schedule

See individual assays

Reference Range

Cardiolipin Ab (IgA)	<20.0 Antibody not detected > or = 20.0 Antibody detected	APL-U/mL
Cardiolipin Ab (IgG)	<20.0 Antibody not detected > or = 20.0 Antibody detected	GPL-U/mL
Cardiolipin Ab (IgM)	<20.0 Antibody not detected > or = 20.0 Antibody detected	MPL-U/mL

Clinical Significance

Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly systemic lupus erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren's syndrome.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.