Apolipoprotein B

Test Code

LAB6005

Quest Code

5224

Alias/See Also

APOB

CPT Codes
82172

Preferred Specimen

1 mL serum

Minimum Volume

0.5 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Grossly lipemic

Methodology
Immunoturbidimetric

Setup Schedule

Set up: Mon-Sat; Report available: 1-2 days

Reference Range

<90 mg/dL

Risk Category
Optimal	<90 mg/dL
Moderate	90-129 mg/dL
High	≥130 mg/dL

A desirable treatment target may be <80 mg/dL or lower depending on the risk category of the patient including patients on lipid lowering therapies, patients with ASCVD, diabetes with >1 risk factors, Stage 3 or greater CKD with albuminuria, or heterozygous familial hypercholesterolemia. ApoB relative risk category cut points are based on AACE/ACE and ACC/AHA recommendations (Grundy SM, et al. 2019. doi:10.1016/j.jacc.2018.11.002; Handelsman Y, et al. 2020. doi:10.4158/CS-2020-0490).

Clinical Significance

Apolipoprotein B (APO B) has been reported to be a powerful indicator of CAD. In some patients with CAD, APO B is elevated even in the presence of normal LDL cholesterol.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

Additional Information
LCD-ABN_Non-Covered_Service_APOB
LMRP_L36358_Cardiovascular_Risk_Assessment_Testing

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.