AD-Detect™ p-tau217/Beta-Amyloid 1-42 Ratio, Plasma (FDA Cleared)

Test Code

LAB###

Quest Code

17970

CPT Codes
84393, 82234

Includes

ptau217
ABeta 42
ptau217/ABeta 42 Ratio

Preferred Specimen

1 mL plasma collected in a K2 EDTA (lavender-top) tube

Minimum Volume

0.75 mL

Instructions

Centrifuge sample within 2 hours of collection and transfer to a polypropylene tube for transport.
Freeze within 24 hours. Transport frozen.

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 24 hours
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Moderate or gross hemolysis

Methodology
Fujirebio Lumipulse Chemiluminescent Enzyme Immunoassay

Setup Schedule

Set up: Mon-Sat; Report available: 3-5 days

Reference Range

ptau217	Not established
ABeta 42	Not established
ptau217/ABeta 42 Ratio	≤0.00370

Clinical Significance

AD-Detect™ p-tau217/Beta-Amyloid 1-42 Ratio, Plasma (FDA Cleared) is cleared by the FDA for assessment of patients aged >=50 years with signs or symptoms of cognitive decline. The levels of two proteins, p-tau217 and Beta-amyloid 1-42, are evaluated within the plasma and calculated into an analytical ratio. This ratio is correlated to the presence or absence of amyloid plaques in the patient's brain, which may reduce the need for an amyloid-PET scan.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.