Encephalopathy, Autoimmune Evaluation, Serum

Test Code
ENS2M


Alias/See Also
ACh Receptor (Muscle) Binding Ab; AMPA-R Ab CBA; Amphiphysin Ab; Anti-Glial Nuclear Ab, Type 1; Anti-Neuronal Nuclear Ab, Type 1; Anti-Neuronal Nuclear Ab, Type 2; Anti-Neuronal Nuclear Ab, Type 3; Behavioral change; CASPR2-IgG; Confusion; Contactin-Associated Protein-Like-2 (CASPR2)-IgG; CRMP-5-IgG; Encephalitis; GABA-B-R Ab CBA; Glutamic Acid Decarboxylase (GAD65); Leucine-Rich Glioma Inactived Protein-1 IgG; LGI1-IgG; Limbic encephalitis; NMDA-R Ab CBA; Psychosis; Purkinje Cell Cytoplasmc Ab Type Tr; Purkinje Cell Cytoplasmic Ab Type 1; Purkinje Cell Cytoplasmic Ab Type 2; GFAP; IGLON5; NIF; ENCES


Preferred Specimen
4 mL serum - Red Top Tube


Patient Preparation
1. For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.

2. This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient.

3. Patient should have no general anesthetic or muscle-relaxant drugs in the previous 24 hours.

Minimum Volume
2.5 mL


Other Acceptable Specimens
Serum - Gold SST


Transport Temperature
Refrigerated (preferred)


Specimen Stability
Room Temperature: 72 hours
Refrigerated: 28 days
Frozen: 28 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly hemolyzed, lipemic, or icteric specimens should be rejected.


Performing Laboratory
Mayo Clinic Laboratories sendout

Additional Information
Mayo Clinic Laboratories Serum Encephalopathy, Autoimmune Evaluation Information

Last Updated: December 3, 2021


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.