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Glycols Panel, Serum
Test CodeGLYCOLSP
CPT Codes
82542
Includes
Propylene Glycol, Serum by GC-FID
Ethylene Glycol, Serum by GC-FID
Diethylene Glycol, Serum by GC-FID
Ethylene Glycol, Serum by GC-FID
Diethylene Glycol, Serum by GC-FID
Preferred Specimen
Red Top Serum
Minimum Volume
0.5 ml Serum from Red top
Instructions
•Collect without the use of a tourniquet or immediately after the application of the tourniquet
•Transport to the Laboratory immediately after collection
•Separate the serum from the cells ASAP
•Transport to the Laboratory immediately after collection
•Separate the serum from the cells ASAP
Transport Container
Aliquot Tube
Specimen Stability
Room Temp – 1 day
Refrigerated – 7 days
Frozen – 30 days
Refrigerated – 7 days
Frozen – 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples past stability, samples other than serum
Methodology
Gas chromatography – flame ionization detection (GC-FID)
FDA Status
LDT
Setup Schedule
7 days per week, 6 am – 9 pm
Report Available
Within 36 hours from receipt at BUMCP
Reference Range
< 10 mg/dL
Clinical Significance
Propylene Glycol (PG)
Propylene glycol (1,2-propanediol) is used in antifreeze, pharmaceuticals, makeup, theatrical smoke, and paint. It is metabolized by alcohol dehydrogenase (ADH) in the liver to form lactic and pyruvic acids, molecules that are normal in the Krebs cycle. Although it is generally considered safe, large doses in a short time can cause metabolic acidosis, acute renal injury, seizure, and/or coma. Propylene glycol toxicity can be treated by limiting the dosage of propylene-containing medications, by administering sodium bicarbonate, by treatment with 4-methylpyrazole (4-MP: fomepizole), and in severe cases, by utilizing hemodialysis.
Ethylene Glycol (EG)
Ethylene glycol is present in antifreeze products, deicing products, detergents, paints, and cosmetics. Ethylene glycol itself is relatively nontoxic, however, metabolism of ethylene glycol by alcohol dehydrogenase (ADH) results in the formation of several acid metabolites, including oxalic acid and glycolic acid. These acid metabolites are responsible for much of the toxicity of ethylene glycol. Symptoms of toxicity vary from mild central nervous system depression to coma, severe metabolic acidosis, and/or renal failure. Ethylene glycol toxicity can be treated with 4-methylpyrazole or ethanol by competitively inhibiting alcohol dehydrogenase and thereby preventing conversion of ethylene glycol to its toxic metabolites.
Diethylene Glycol (DEG)
Diethylene glycol is used in antifreeze, brake fluids, cosmetics, lubricants, and other commercially available products. Toxic concentrations may cause intoxication, CNS depression, metabolic acidosis, renal damage, and hypocalcemia. Diethylene glycol is extremely toxic. Ingestion can be fatal if patients do not receive immediate medical treatment.
Propylene glycol (1,2-propanediol) is used in antifreeze, pharmaceuticals, makeup, theatrical smoke, and paint. It is metabolized by alcohol dehydrogenase (ADH) in the liver to form lactic and pyruvic acids, molecules that are normal in the Krebs cycle. Although it is generally considered safe, large doses in a short time can cause metabolic acidosis, acute renal injury, seizure, and/or coma. Propylene glycol toxicity can be treated by limiting the dosage of propylene-containing medications, by administering sodium bicarbonate, by treatment with 4-methylpyrazole (4-MP: fomepizole), and in severe cases, by utilizing hemodialysis.
Ethylene Glycol (EG)
Ethylene glycol is present in antifreeze products, deicing products, detergents, paints, and cosmetics. Ethylene glycol itself is relatively nontoxic, however, metabolism of ethylene glycol by alcohol dehydrogenase (ADH) results in the formation of several acid metabolites, including oxalic acid and glycolic acid. These acid metabolites are responsible for much of the toxicity of ethylene glycol. Symptoms of toxicity vary from mild central nervous system depression to coma, severe metabolic acidosis, and/or renal failure. Ethylene glycol toxicity can be treated with 4-methylpyrazole or ethanol by competitively inhibiting alcohol dehydrogenase and thereby preventing conversion of ethylene glycol to its toxic metabolites.
Diethylene Glycol (DEG)
Diethylene glycol is used in antifreeze, brake fluids, cosmetics, lubricants, and other commercially available products. Toxic concentrations may cause intoxication, CNS depression, metabolic acidosis, renal damage, and hypocalcemia. Diethylene glycol is extremely toxic. Ingestion can be fatal if patients do not receive immediate medical treatment.
Performing Laboratory
Banner University Medical Center Phoenix
