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High Density Lipoprotein Cholesterol
MessagePerformed in Chemistry
Test Code
HDL
CPT Codes
83718
Preferred Specimen
Green Top LiHep, Plasma
WyMCC - SST
WyMCC - SST
Other Acceptable Specimens
Gold/SST, Red Top
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Do not use fluride plasma
Collected in an outdated/expired tube
Hemolyzed, icteric or lipemic
Contaminated
Collected in an outdated/expired tube
Hemolyzed, icteric or lipemic
Contaminated
FDA Status
FDA Approved
Setup Schedule
Daily, Sunday through Saturday
Report Available
Less than 4 hours
Clinical Significance
High density lipoproteins (HDL) are responsible for the reverse transport of cholesterol from the peripheral cells to the liver. In the liver, cholesterol is transformed to bile acids which are then excreted into the intestine via the biliary tract. Monitoring of HDL-cholesterol in serum or plasma is of clinical relevance as the HDL-cholesterol concentration is important in the assessment of atherosclerotic risk. Elevated HDL-cholesterol concentrations protect against coronary heart disease (CHD), whereas reduced HDL-cholesterol concentrations, particularly in conjunction with elevated triglycerides, increase cardiovascular risk. A variety of methods are available to determine HDL-cholesterol, including ultracentrifugation (reference method in combination with cholesterol measurement by the Abell-Kendall method), electrophoresis, HPLC, precipitation, and direct methods. Of these, the direct methods are used routinely. Roche HDLC4 is also a direct method. The automated HDLC4 assay uses detergents, cholesterol esterase (CHER), cholesterol oxidase (CHOD) and peroxidase to form a colored pigment that is measured optically. The HDLC4 assay meets the 1998 National Institutes of Health (NIH) / National Cholesterol Education Program (NCEP) goals for precision and accuracy.
