N-Methylhistamine, Urine

Message

Order as ESOT to MAYO

Test Code

PESOT/ESOT NMH24

Alias/See Also

MAYO test code NMH24
1-Methylhistamine
Histamine Metabolites
Urinary N-Methylhistamine

CPT Codes
82542

Preferred Specimen

5.0 mL Urine

Minimum Volume

3.0 mL Urine

Instructions

Collection Instructions:
1. Collect urine for 24 hours.
2. No preservative.
Additional Information:
1. 24-Hour collection is preferred, but a random specimen is also acceptable.
2. See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections

See link below for specimen details, methodology, setup schedule and reference ranges.

Transport Container

Urine collection tube

Transport Temperature

Refrigerated

Specimen Stability

Ambient 24 hours
Refrigerated 8 days
Frozen 14 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Methodology
NMH: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
NCTU: Enzymatic Colorimetric Assay

FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Setup Schedule

Tuesday, Thursday 10 am

Report Available

Analytic time 3 days
Maximum lab time 7 days

Reference Range

0-5 years: 120-510 mcg/g creatinine
6-16 years: 70-330 mcg/g creatinine
>16 years: 30-200 mcg/g creatinine

Clinical Significance

Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis

Performing Laboratory
Mayo Medical Laboratories
Rochester

Additional Information
N-Methylhistamine, 24 Hour, Urine

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.