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Heparin Induced Platelet Antibody IgG
MessagePerformed at BUMCT
Test Code
HITE
Preferred Specimen
Plasma collected in: 3.2% sodium citrate (light blue-top) tube
Instructions
Na citrate tube, pour off 2 plasma aliquots
Specimen Stability
2 - 8 degrees 8 hours or less
- 20 degrees 2-3 years
- 20 degrees 2-3 years
Methodology
Immucor PF4 IgG ELISA assay
Setup Schedule
Mon - Wed - Fri (except holidays)
Note - specimen deadline is 10am on day of run
Note - specimen deadline is 10am on day of run
Report Available
By 1600 on the day of run
Clinical Significance
Heparin Induced Thrombocytopenia (HIT) is a serious immune-mediated complication of heparin therapy affecting 1 –
4% of patients receiving the drug. HIT occurs when IgG antibodies are formed against a neoantigen created by
complexes of heparin and platelet factor 4. These antibodies activate platelets, resulting in thrombocytopenia and
thrombosis.
4% of patients receiving the drug. HIT occurs when IgG antibodies are formed against a neoantigen created by
complexes of heparin and platelet factor 4. These antibodies activate platelets, resulting in thrombocytopenia and
thrombosis.
