D-Dimer - Quantitative

Message

Performed in Coagulation

Test Code

DDIQ

CPT Codes
85380

Preferred Specimen

3.2% sodium citrate - blue top tube
Wyoming- Mesa and Sage - EDTA

Instructions

Full blue top tube or 1.0 mL plasma frozen.

The light blue capped tubes, containing 3.2% buffered sodium citrate, used for coagulation testing must be allowed to fill completely (after filling a small air space will normally be present). For patients having a hematocrit greater than 55%, contact the hospital coagulation department to obtain a special collection tube.

Transport Temperature

Room temp, refrigerated, Frozen

Specimen Stability

Whole Blood Na Cit on heparin – ambient -1 hr

Whole blood Na Cit (unopen/unspun) ambient -24 hours

Plasma Na Cit (open/spun) ambient -24 Hr.

Plasma Na Cit double spun and separated, Frozen –20C - 2 weeks

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Clotted
Serum received instead of Sodium Citrate plasma
Specimen past stability
Frozen plasma received thawed
Underfilled or Overfilled, blood/anticoagulant ratio must be 9/1; Specimens must be between 90% -110% full
Collected in a 3.8% Sodium Citrate tube instead of 3.2% Sodium Citrate tube
Drawn in outdated/expired tube
Hemolyzed, icteric, or lipemic sample

Setup Schedule

Monday through Sunday; Continuously

Report Available

Same day

Reference Range

System Standard: Male < 500 ng/mL FEU Female < 500 ng/mL FEU

WyMC:

Clinical Significance

The determination of D-Dimer is becoming a widespread tool for diagnosing thrombosis and monitoring thrombolytic therapy.

Elevated levels of D-Dimer are found in clinical conditions such as deep vein thrombosis (DVT, pulmonary embolism (PE) and disseminated intravascular coagulation (DIC). D-Dimer levels also rise during the normal pregnancy, but very high levels are associated with complications. A negative D-Dimer result when combined with a clinical assessment of low pretest probability has been shown to have a high negative predictive value for DVT or PE. D-Dimer results in human citrated plasma from IL Coagulation systems in conjunction with a clinical pretest probability (PTP) assessment model can exclude venous thromboembolism in outpatients suspected of deep venous thrombosis and pulmonary embolism.

While a positive D-Dimer alone is not diagnostic of DVT or PE, a negative D-Dimer can be used to exclude the diagnosis of venous thrombosis. There are a number of articles available that discuss the choice of cut-off value for ruling out venous thrombosis.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.