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Methotrexate
MessagePerformed in Chemistry at BUMCP or BDMC for Az facilities besides Tucson
BUMCT performs for BUMCT, BUMCS, NCC and OG
Specimens sent to BUMCT and BUMCP should be protected from light.
If Ordered TS, ES or ST then send via ST Courier to testing facility
Performed at NCMC for OCH
BUMCT performs for BUMCT, BUMCS, NCC and OG
Specimens sent to BUMCT and BUMCP should be protected from light.
If Ordered TS, ES or ST then send via ST Courier to testing facility
Performed at NCMC for OCH
Test Code
MTX
CPT Codes
80299
Preferred Specimen
Red
Minimum Volume
Full tube
Other Acceptable Specimens
Li Heparin, EDTA
FDA Status
FDA Approved
Setup Schedule
Daily, Sunday through Saturday
Report Available
BUMCP- Report available within 4 hours from receipt at testing facility.
Clinical Significance
Methotrexate [N-[4[[(2,4-diamino-6-pteridinyl) methyl] methylamino]benzoyl]-L-glutamic acid],formerly Amethopterin, is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. Methotrexate has the potential for serious toxicity. Patients undergoing methotrexate therapy should be closely monitored so that toxic effects are detected promptly. Guidelines for methotrexate therapy with leucovorin rescue should be consulted. Intermediate to high doses of methotrexate (approximately 35 mg/m2 - 12 g/m2) with leucovorin (citrovorum-factor) rescue have been used with favorable results in the treatment of osteogenic sarcoma, leukemia, non-Hodgkin’s lymphoma, lung and breast cancer.
Performing Laboratory
system
