Tobramycin, Trough

Message

Performed in Chemistry
Performed at BDMC; Serves BBMC, BDMC, BGMC, BGFMC, BIMC
Performed at BUMCP; Serves BBWMC, BDWMC, BEMC, BUMCP, BTMC
Performed at BUMCT; Serves BUMCT, BUMCS, CCN, CCOG

Test Code

TOBRAT

CPT Codes
80200

Preferred Specimen

Green top LiHep, Plasma

Minimum Volume

1 ml peds
3 ml adult

Other Acceptable Specimens

Gold/SST, Red

Specimen Stability

Refrigerated - 3 days
Frozen - 1 month

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Collected in an outdated/expired tube
Hemolyzed, icteric or lipemic
Contaminated

FDA Status
FDA Approved

Setup Schedule

Daily, Sunday through Saturday

Report Available

Less than 4 hours

Clinical Significance

Tobramycin is an aminoglycoside antibiotic used in the treatment of infections caused by Pseudomonas aeruginosa, Proteus species, E. coli, Klebsiella, Serratia, Citrobacter, Staphylococcus aureus, Enterobacter and other microorganisms. Tobramycin’s toxic effect is produced by interfering with ribosomal protein synthesis.1 Tobramycin undergoes very little, if any, metabolization and is, therefore, eliminated as the parent drug by glomerular filtration. The half-life of tobramycin in serum or plasma correlates closely with renal function and thus is quite variable between individuals and within one individual over time.2,3 Serum or plasma tobramycin concentration is also impacted by mode of administration, the volume of extracellular fluid, the duration of the treatment and physiological changes during the illness and therapy. The therapeutic range of tobramycin should be measured at peak as well as trough concentrations. In patients with pre-existing renal damage or those to whom tobramycin has been administered for prolonged periods or in doses above the therapeutic range, hearing impairment and/or nephrotoxicity may develop. Therefore, monitoring of peak and trough tobramycin serum or plasma levels is critical in the prevention of these serious complications with the adjustment of dosage administration as indicated.4

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.