Porphyrins, Fractionated, Quantitative, Random Urine

Message

Alert: The test being ordered is a genetic test for an inherited disease which is indicated once in a lifetime. The test has already been performed and the results are available. Repeat genetic testing should only be performed if the existing result is inconsistent with the patient’s clinical presentation or if the methodology has changed to the extent that a different result from the original one would impact patient management. If a repeat test is being requested please contact the Laboratory to discuss the reason it is being ordered. Duplicate request for this order will be canceled.

Test Code

RUPFQ

Quest Code

36592

Alias/See Also

36592

CPT Codes
84120

Includes

Coproporphyrin I, Coproporphyrin III, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Uroporphyrin I, Uroporphyrin III, Total Porphyrins

Preferred Specimen

2 mL random urine in 5 g sodium carbonate container or no preservative container - protected from light

Minimum Volume

1.5 mL

Other Acceptable Specimens

Catheterized urine • First void clean catch urine • Random clean catch urine collected with no preservative

Instructions

Random urine collected with 5 grams of sodium carbonate, refrigerated and protected from light during collection is preferred.
Collection with no preservative is acceptable, if properly refrigerated and light protected.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature • Samples not protected from light • Samples with a pH <4.0

Methodology
High Performance Liquid Chromatography (HPLC)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Sun, Tues-Fri; Report available: 5-7 days

Reference Range

Uroporphyrin I	3.6-21.1 mcg/g creat
Uroporphyrin III	≤5.6 mcg/g creat
Heptacarboxyporphyrin	≤3.4 mcg/g creat
Hexacarboxyporphyrin	≤6.3 mcg/g creat
Pentacarboxyporphyrin	≤4.1 mcg/g creat
Coproporphyrin I	6.5-33.2 mcg/g creat
Coproporphyrin III	4.8-88.6 mcg/g creat
Total Porphyrins	27.0-153.6 mcg/g creat

Clinical Significance

Clinical use is to diagnose porphyria cutanea tarda, hereditary coproporphyria, variegate porphyria.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.