| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Prealbumin
MessagePerformed in Chemistry
Performed at Sonora Quest Laboratories for BCGMC, Page, BCCH, BPMC and BEMC, test 9628
Performed at WyMCC for WMC, TCH and PMCH
Performed at Sonora Quest Laboratories for BCGMC, Page, BCCH, BPMC and BEMC, test 9628
Performed at WyMCC for WMC, TCH and PMCH
Test Code
PREALB
Alias/See Also
TTR
Transthyretin
Transthyretin
CPT Codes
84134
Preferred Specimen
Gold/SST
Other Acceptable Specimens
Red top
Instructions
For facilities sending to Sonora Quest Laboratories, see link below for specimen details, methodology, setup schedule and reference ranges.
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolyzed, icteric or lipemic
FDA Status
FDA Approved
Setup Schedule
Daily, Sunday through Saturday
Report Available
Less than 4 hours
Clinical Significance
Prealbumin is a tryptophan-rich protein which is synthesized in hepatocytes and has a molar mass of 55000 daltons. At a pH of 8.6, an electrophoretic band appears prior to albumin in a relative amount of < 2.5 % due to its greater rate of diffusion to the anode. Its function is to bind and transport low molecular weight retinol-binding proteins (molar mass of less than 21000 daltons), preventing their glomerular filtration. 30-50 % of circulating prealbumin is complexed by retinol-binding protein. Furthermore, it binds and transports thyroxine (T4), nevertheless its affinity to this hormone is less than that of thyroxine-binding globulin. Prealbumin has a short half-life of approximately 2 days. Accordingly, decreased hepatocellular synthesis caused by acute liver damage or dietary protein deficiency elicits a very rapid decrease in serum prealbumin levels. According to the literature, prealbumin can act as a negative acute phase reactant, with its concentration decreasing rapidly during inflammatory processes.
Additional Information
Prealbumin
