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Osmolality, Serum
Test CodeOSMO
Alias/See Also
Performed in Chemistry for most locations:
BGFMC sends to BIMC
BUMCS sends to BUMCT
BCCH, Page send to Sonora Quest Laboratories,Test code 9290
BGFMC sends to BIMC
BUMCS sends to BUMCT
BCCH, Page send to Sonora Quest Laboratories,Test code 9290
CPT Codes
83930
Preferred Specimen
Li Heparin tube for facilities performing on site
Other Acceptable Specimens
SST/gold top tube
Instructions
For SQL sites, see link below for specimen details, methodology, setup schedule and reference ranges.
Setup Schedule
On-Site testing: Less than 4 hrs
SQL: Setup Nights: Monday through Sunday
SQL: Setup Nights: Monday through Sunday
Clinical Significance
Osmolality is used to evaluate the concentrating ability of the tubules in the kidneys.
Low serum or plasma osmolality levels are seen in adrenocortical insufficiency, panhypopituitarism, water intoxication and
postoperative status, (especially with excessive water replacement therapy, syndrome of inappropriate ADH secretion).
High serum or plasma osmolality levels are seen with water depletion, hyper-osmolar, nonketotic diabetic coma, diabetic
ketoacidosis, hypernatremic ethanol intoxication, diabetes insipidus, hypercalcemia, cerebral lesions, and often with tube feeding.
Low urine osmolality levels are seen with diabetes insipidus and primary polydipsia. After fluid restriction of 12-14 hours, a patient
with normal renal function should be able to concentrate urine to at least 800 mOsm/kg. Loss of this function is seen in early renal
failure, and a concentration ability of only 400 mOsm/kg would indicate severe renal dysfunction.
Low serum or plasma osmolality levels are seen in adrenocortical insufficiency, panhypopituitarism, water intoxication and
postoperative status, (especially with excessive water replacement therapy, syndrome of inappropriate ADH secretion).
High serum or plasma osmolality levels are seen with water depletion, hyper-osmolar, nonketotic diabetic coma, diabetic
ketoacidosis, hypernatremic ethanol intoxication, diabetes insipidus, hypercalcemia, cerebral lesions, and often with tube feeding.
Low urine osmolality levels are seen with diabetes insipidus and primary polydipsia. After fluid restriction of 12-14 hours, a patient
with normal renal function should be able to concentrate urine to at least 800 mOsm/kg. Loss of this function is seen in early renal
failure, and a concentration ability of only 400 mOsm/kg would indicate severe renal dysfunction.
Additional Information
Osmolality
