ADmark® ApoE Genotype Analysis and Interpretation (Symptomatic)

Test Code

APO E GENOTYPE(O)

CPT Codes
81401

Includes

ADmark ApoE Genotype Analysis and Interpretation and is useful to detect ApoE2, E3, and E4 alleles. ADmark assays should only be ordered for patients with symptoms of dementia and are not appropriate for asymptomatic individuals.

Please note: Athena does not perform ApoE testing for individuals under the age of 18. Pre-test and post-test genetic counseling is strongly recommended.

Preferred Specimen

8 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

6 mL whole blood • 3 mL saliva

Other Acceptable Specimens

4 mL saliva collected in an OGD-500 Oragene-Dx or OGD-600 Oragene Dx collection kit

Instructions

Sample must be noted as "symptomatic" and patient must be 18 years or older. Samples not noted as "symptomatic" and samples for patients under 18 years of age will be rejected by Athena.

Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing. DNA yields and quality are better in fresh specimens. However, when necessary, most genetic tests are successful from DNA purified from whole blood that is several days old. Immediate shipping is recommended to optimize DNA quality and quantity

For best results, specimens should arrive at Chantilly Monday through Thursday within 24 hours of collection. Do not submit on a day before a holiday. Do not freeze whole blood specimens.

Transport Temperature

Room temperature

Specimen Stability

Whole blood
Room temperature: 10 days
Refrigerated: 10 days
Frozen: 90 days

Saliva
⁠⁠⁠⁠⁠⁠⁠Room temperature: 1 year
Refrigerated: Unacceptable
Frozen: Unacceptable

Methodology
Restriction Fragment Length Polymorphism (RFLP)

FDA Status
⁠⁠⁠⁠⁠⁠⁠This test was developed and its performance characteristics have been determined by Athena Diagnostics. Performance characteristics refer to the analytical performance of the test.

Setup Schedule

Set up: Varies; Report available: 7-14 days

Reference Range

See Laboratory Report

Clinical Significance

Detection of APOE2, E3, E4 alleles.

Last Updated: October 13, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.