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Nurse Driven Heparin Protocol
MessageThe below tests are only for the NDHP (Nurse driven heparin protocol) being piloted in West Roxbury. Test is ordered Ward Collect via a special menu in CPRS and cannot be added on to samples already in the Lab.
Test Code
NURSE PTT, NURSE ANTI XA
Alias/See Also
Hematology
Preferred Specimen
Light Blue Top Tube – 3.2% sodium citrate
Transport Temperature
Best stored at room temp. Cold temps may lead to a gradual loss of VFW and Factor VIII activity. Do not transport directly on ice packs or on ice.
Specimen Stability
Nurse PTT:
Whole Blood
Patients on unfractionated heparin – deliver to laboratory ASAP
Room temperature: 1 hour
Patients on direct oral anticoagulants
Room temperature: 2 hours
Patients on heparin other than unfractionated/direct oral anticoagulants
Room temperature: 6 hours
Nurse Anti-XA
Whole Blood
Room temperature: 1 hour – bring to laboratory ASAP
Aliquoted plasma
Room temperature: 1 hour
Whole Blood
Patients on unfractionated heparin – deliver to laboratory ASAP
Room temperature: 1 hour
Patients on direct oral anticoagulants
Room temperature: 2 hours
Patients on heparin other than unfractionated/direct oral anticoagulants
Room temperature: 6 hours
Nurse Anti-XA
Whole Blood
Room temperature: 1 hour – bring to laboratory ASAP
Aliquoted plasma
Room temperature: 1 hour
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Underdrawn or grossly hemolyzed specimens are not acceptable.
Methodology
Photo-optical endpoint
Setup Schedule
Daily
Report Available
TAT 1 day
Reference Range
Nurse PTT
27.9 – 37.0 sec
Therapeutic heparinized range: 55.0 - 94.0 sec
Nurse Anti-Xa
0.3-0.7 IU/mL
27.9 – 37.0 sec
Therapeutic heparinized range: 55.0 - 94.0 sec
Nurse Anti-Xa
0.3-0.7 IU/mL
Performing Laboratory
Test performed in the WX Hematology Lab
Contact West Roxbury: Nolan Raymond 857-203-5980
Last Updated: September 19, 2025