Yo Antibody Screen with Reflex to Titer and Western Blot, CSF

Message

If CJD is suspected - please contact the Laboratory.

This test is currently only available in BHS CPRS. If you are a Bedford provider and wish to see this test offered in Bedford CPRS- please contact the Bedford Laboratory.

Testing performed at Quest Diagnostics.

Test Code

YO AB PANEL,CSF(O)

CPT Codes
86255

Includes

If Yo Antibody Screen, IFA, CSF is positive, then Yo Antibody, Western Blot, CSF will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot, CSF is positive, then Yo Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).

Preferred Specimen

0.8 mL CSF collected in a sterile, plastic leak-proof container

Patient Preparation
Overnight fasting is preferred

Minimum Volume

0.5 mL

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 6 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature

Methodology
Immunofluorescence Assay (IFA)

FDA Status
This test was developed and its performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the test.

Setup Schedule

Set up: Mon, Wed, Fri; Report available: 4 days

Reference Range

Yo Ab Screen, IFA, CSF

Negative

Yo Ab, WB, CSF	Negative
Yo Ab, Titer, CSF	No Yo Antibodies detected in undiluted CSF sample

Clinical Significance

Purkinje Cell (Yo) antibody is found in approximately half of the patients with paraneoplastic cerebellar degeneration and is associated with ovarian, uterine, and small cell lung carcinomas and Hodgkin’s lymphoma.

Last Updated: September 24, 2014

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.