BRCA1 and BRCA2 Analysis Panel

Message

Test cost $2200
This test is currently only available in BHS CPRS. If you are a Bedford provider and wish to see this test offered in Bedford CPRS- please contact the Bedford Laboratory.

Test Code

BRCA1 AND BRCA2 ANALYSIS PANEL

Alias/See Also

BRAC
HBOC
Hereditary breast-ovarian cancer syndrome

Preferred Specimen

6 Purple top tubes, whole blood

Instructions

Wait at least two weeks after a packed cell or platelet transfusion and at least four weeks after a whole blood transfusion prior to blood draw.

Transport Temperature

Room Temperature

Specimen Stability

Refrigerated
DO NOT FREEZE!

Methodology
Deletion/Duplication Analysis, Gene Sequence Analysis, Specific Site Analysis

Report Available

< 14 days

Reference Range

Provided with the patient report in CPRS.

Clinical Significance

Hereditary breast-ovarian cancer (HBOC) syndrome is an autosomal dominant cancer predisposition syndrome caused by germline BRCA1/2 mutations. Mutations in these two highly penetrant genes increase the chance for cancer of the breast, ovaries and fallopian tubes, pancreas and prostate.3 Studies suggest female BRCA1 mutation carriers have between a 57-87% risk to develop breast cancer and between a 39-40% risk to develop ovarian cancer by age 70. Similarly male BRCA1 mutation carriers have a cumulative breast cancer risk of 1.2% by age 70.

Performing Laboratory
Test performed at Ambry Genetics and transported via Quest.

Additional Information
Link to test information on AmbryGenetics website

Last Updated: November 3, 2015

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.