Lyme Disease Antibody Index for CNS Infection

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If CJD is suspected - please contact the Laboratory

This test is currently only available in BHS CPRS. If you are a Bedford provider and wish to see this test offered in Bedford CPRS- please contact the Bedford Laboratory.

Testing performed at Quest Diagnostics.

Test Code

B.BURGDORFERI AB INDEX(O)

CPT Codes
82040, 82042, 82784 (x2), 86618 (x4)

Preferred Specimen

2 mL serum collected in a serum separator tube (SST) and
2 mL CSF collected in a leak-proof CSF container, within a 24-hour period

Minimum Volume

1 mL serum • 1 mL CSF

Instructions

2 mL serum and 2 mL CSF collected within a 24-hour period

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

CSF and serum collected greater than 24 hours apart

Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA) • Nephelometry

Setup Schedule

Set up: Tues, Fri; Report available: 2-6 days

Reference Range

Lyme Disease Antibody Index

≤1.0	Negative
1.1-1.2	Equivocal
≥1.3	Positive

Control Antibody Index	≤1.0
Albumin Ratio	<0.0078

Clinical Significance

The Lyme disease antibody index is used as an aid for diagnosing neuroborreliosis. The assay requires paired serum and CSF. A result set of lyme disease antibody index >1.2, control antibody index <1.0, and albumin ratio <0.0078 provides strong evidence of intrathecal synthesis of b. Burgdorferi antibodies and supports the diagnosis of neuroborreliosis.

Last Updated: October 29, 2014

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.