CYP2C19 Genotype

Test Code

CYP2C19 GENOTYPE(WH)

Alias/See Also

Cytochrome p450 2C19
Clopidogrel Genotype
Plavix Genotype

Preferred Specimen

Whole blood lavender EDTA

Instructions

Do not centrifuge or freeze

Transport Temperature

Refrigerated (2-8°C)

Methodology
GenMark eSensor PCR, electrochemical detection - LDT

Setup Schedule

Once per week

Report Available

8 Days

Reference Range

CYP2C19 Genotype *1*1

Clinical Significance

This test is validated to detect the most common CYP2C19 alleles *1, *2, *3, and *17. CYP2C19*1 is a presumptive finding when a variant is not detected. The existence of rare variants cannot be ruled out. Because CYP2C19 genotyping does not capture all the variability of drug response, results must be interpreted in the context of other results, co-administered drugs, and clinical findings.
CPIC CYP2C19-Related Drug Dosage Guidelines & References
References: Clin Pharm Ther 2013; 94:317-323 and http://pharmgkb.org/gene/PA124.
Amytriptyline: http://www.pharmgkb.org/guideline/PA166105006
Clomipramine: http://www.pharmgkb.org/guideline/PA166105007
Clopidogrel: http://www.pharmgkb.org/guideline/PA166104948
Doxepin: http://www.pharmgkb.org/guideline/PA166105000
Imipramine: http://www.pharmgkb.org/pmid/23486447
Trimipramine: http://www.pharmgkb.org/guideline/PA166105001

Performing Laboratory
Test performed at the VA Connecticut Molecular Diagnostics Laboratory
Contact: Tricia Cavallaro 203-932-5711
Ext: 2915/2919
Fax: 203-937-4786

Last Updated: May 16, 2018

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.