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Vancomycin, Trough
Test CodeVANCOMYCIN(TROUGH)
Alias/See Also
Chemistry
Preferred Specimen
Plain Red Top Tube
Minimum Volume
2 mL
Instructions
PRE (TROUGH) LEVELS should be obtained before the next drug dose under steady state conditions.
Transport Temperature
Refrigerate
Specimen Stability
Room temperature: 3 days. Separate if not tested within this time.
Refrigerated (2-8°C): 8 days
Frozen (-20°C or colder): 3 months
Refrigerated (2-8°C): 8 days
Frozen (-20°C or colder): 3 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Collected in gel tube
Methodology
Chemiluminescent microparticle immunoassay
Setup Schedule
Daily
Report Available
TAT 1 - 3 days
Reference Range
10-20 ug/ml
For COMPLICATED INFECTIONS such as bacteremia, endocarditis, meningitis and hospital acquired pneumonia caused by S. aureus, recommended TROUGH level is 15-20 ug/mL. For uncomplicated infections, troughs of 10-15 ug/mL may be adequate. Trough therapeutic range was increased to address evidence based guidelines for Vancomycin use aimed at improving efficacy of antibiotics for serious infections & reducing emergence of resistant strains.
For COMPLICATED INFECTIONS such as bacteremia, endocarditis, meningitis and hospital acquired pneumonia caused by S. aureus, recommended TROUGH level is 15-20 ug/mL. For uncomplicated infections, troughs of 10-15 ug/mL may be adequate. Trough therapeutic range was increased to address evidence based guidelines for Vancomycin use aimed at improving efficacy of antibiotics for serious infections & reducing emergence of resistant strains.
Clinical Significance
Vancomycin is an antibiotic used in the treatment of serious bacterial infections, especially methicillin-resistant staphylococci. Vancomycin is also used in treatment for penicillin-allergic patients who cannot receive or have failed to respond to other drugs, including the penicillins and/or cephalosporins and for other infections caused by vancomycin-susceptible organisms.
Performing Laboratory
Test performed at West Roxbury, Brockton and Bedford Chemistry Labs
Contact: Jonathan Dryjowicz-Burek 857-203-5973
Alternate contact Diane Robert Brockton 774-826-2294
Alternate contact Bhumikaben Patel Bedford 781-687-2976
Last Updated: August 6, 2021
