D-Dimer (quant)

D-DIMER QT-ROUTINE

D DIMER
Hematology

Light Blue Top Tube – 3.2% sodium citrate

Refrigerate. Freeze plasma if sample is not tested within 24 hours.

Specimens stored as whole blood can be maintained uncentrifuged or centrifuged, with plasma remaining on top of cells, in an unopened tube at room temperature (18-25 degrees C), can have plasma tested for up to 24 hours from time of specimen collection. Specimens stored as aliquoted plasma are good for 24 hours at room temperature (18-25 degrees C) or refrigerated (2-8 degrees C), 2 weeks at -20 degrees C and 12 months at -70 degrees C.

Daily

TAT 1 day

0 - 230 ng/mL

D-Dimer (units: DD-U) assay and associated reference range is FDA approved for the exclusion of deep vein thrombosis and/or pulmonary embolism. Effective 6/19/14 cut-off value for exclusion of venous thromboembolism is 230ng/ml, based on manufacturer studies.

A low risk/probability of pulmonary embolism has been reported in patients ≥50 years of age with either a low clinical test probability (Wells score of 0-4) and a D-dimer value of ≤ 1000 ng/mL OR a moderate clinical test probability (Wells score of 4.5-6) and a D-dimer value of ≤ 500 ng/mL.

 

D-Dimer is one of the measurable by-products of activation of the fibrinolytic system. Quantitation of D-Dimer assesses fibrinolytic activation and intravascular thrombosis. D-Dimer is of particular value in excluding the diagnosis of venous thromboembolism among patients at high risk.