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Ionized calcium, Arterial
Test CodeCALCIUM, ION. ARTER
Alias/See Also
Calcium, ionized, arterial
Preferred Specimen
Arterial blood in syringe ON ICE
Transport Temperature
Transport on ice.
Specimen Stability
Stable on ice up to 2 hours.
Methodology
Electrochemical
Setup Schedule
Daily
Report Available
TAT 1 -3 days
Reference Range
4.5 – 5.3 mg/dL
Clinical Significance
The ionized calcium is determined by an ion selective electrode methodology. The result that is generated is pH adjusted. The result is empirically based on a measured pH and ionized calcium concentration normalized to a pH of 7.40. This calculation compensates for in vitro changes in pH due to loss of CO2 through specimen handling. Ionized calcium represents the true "bioavailable" calcium in the circulation. In situations where the total calcium is normal but does not fit the clinical picture, e.g., hyperparathyroidism, a determination of the ionized calcium will, many times, show an elevation in the "bioavailable" calcium component. This may be due to alterations in protein concentrations, especially albumin, that binds most of the calcium in the circulation.
Performing Laboratory
Test performed at West Roxbury Chemistry Lab
Contact: Jonathan Dryjowicz-Burek 857-203-5973
Last Updated: April 4, 2019