Beta 2 microglobulin

Test Code

BETA 2 MICROGLOBULIN

Alias/See Also

B2M

Preferred Specimen

Serum from BLOOD (PLAIN RED)

Minimum Volume

2 mL

Transport Temperature

Refrigerate

Specimen Stability

Room temperature: 1 day
Refrigerated (2-8°C): 3 days
Frozen (-20°C or colder): 6 months

Methodology
The Alinity c β2-Microglobulin automated latex enhanced immunoassay is used for the quantitative in vitro determination of β2-microglobulin (B2-M) in human serum using the Alinity c analyzer as an aid in the diagnosis of active rheumatoid arthritis and kidney disease.
The Alinity c β2-Microglobulin reagent is a suspension of polystyrene latex particles of uniform size coated with the IgG fraction of an anti-human β2-microglobulin specific serum. When a sample containing β2-microglobulin is mixed with the latex reagent and the reaction buffer included in the kit, agglutination occurs. The degree of agglutination is directly proportional to the concentration of β2-microglobulin in the sample, and is determined by measuring the decrease of transmitted light caused by the aggregates.5, 6
Methodology: Turbidimetric/Immunoturbidimetric
Patient results determined by assays using different manufacturers or methods may not be comparable.

Setup Schedule

M-F

Report Available

TAT 1 - 2 days

Reference Range

0.97 - 2.64 mg/L

Clinical Significance

Beta-2-microglobulin normally passes through the glomerulus into the proximal tubule where much of it is reabsorbed. Serum levels are therefore an index of glomerular function. When impaired, serum levels rise in inverse ratio to glomerular filtration rate. Increased amounts of beta-2-microglobulin are excreted in several renal disorders, e.g., Balkan nephropathy, heavy metal poisoning and renal tubular disease due to therapeutic agents. Serial levels of beta-2-microglobulin in serum and urine are used to evaluate transplant viability and anticipate rejection. Following a successful graft, serum levels decline toward normal. Increasing serum levels provide an early sign of rejection. Elevated levels are also noted in lymphproliferative disorders, neoplasms (malignant and benign), inflammatory disease, and autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjögren's disease.

Performing Laboratory

Test performed at West Roxbury Chemistry Lab
Contact: Jonathan Dryjowicz-Burek 857-203-5973

Last Updated: December 19, 2025

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