Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS

Message

This test is currently only available in BHS CPRS. If you are a Bedford provider and wish to see this test offered in Bedford CPRS- please contact the Bedford Laboratory.
Testing performed at Quest Diagnostics.

Test Code

ALDOS/RENIN RATIO PANEL (O)

CPT Codes
82088, 84244

Includes

Aldosterone, LC/MS and Plasma Renin Activity, LC/MS/MS

Preferred Specimen

1.8 mL frozen plasma collected in an EDTA (lavender-top) tube

Minimum Volume

0.8 mL

Instructions

Collect a mid-morning blood sample after patient has been upright (sitting, standing, or walking) for a minimum of 2 hours, then have them sit 5-15 minutes prior to collection.

Transport Temperature

Frozen

Specimen Stability

Room temperature: 24 hours
Refrigerated: 24 hours
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Moderate to gross hemolysis • Plasma collected in a plasma separator tube • Received thawed

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Night Sets up 6 days a week

Reference Range

Aldosterone

Adult
Upright 8:00-10:00 A.M.	≤28 ng/dL
Upright 4:00-6:00 P.M.	≤21 ng/dL
Supine 8:00-10:00 A.M.	3-16 ng/dL
Pediatric
1-12 Months	2-70 ng/dL
1-4 Years	2-37 ng/dL
5-9 Years	≤9 ng/dL
10-13 Years	≤21 ng/dL
14-17 Years	≤35 ng/dL
Infants
Premature (31-35 Weeks)	≤144 ng/dL
Term	≤217 ng/dL
Tanner Stages
II-III Males	1-13 ng/dL
II-III Females	2-20 ng/dL
IV-V Males	3-14 ng/dL
IV-V Females	4-32 ng/dL

Plasma Renin Activity	0.25-5.82 ng/mL/h
Aldosterone/PRA Ratio	0.9-28.9 Ratio

Clinical Significance

The Aldosterone-renin ratio is used to screen for primary aldosteronism.

Last Updated: April 20, 2018

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.