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Methylmalonic Acid, Urine with Creatinine
MessageThis test is currently only available in BHS CPRS. If you are a Bedford provider and wish to see this test offered in Bedford CPRS- please contact the Bedford Laboratory.
Testing performed at Quest Diagnostics.
Testing performed at Quest Diagnostics.
Test Code
MMA URINE PANEL(O)
CPT Codes
82570, 83921
Preferred Specimen
1.7 mL urine - no preservative in a sterile screw cap container
Minimum Volume
0.6 mL
Other Acceptable Specimens
In a sterile, screw-cap container (no preservative): 24-hour urine • Random clean-catch urine • Catheterized urine • First void clean-catch
Instructions
Do not use preservatives
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 4 days
Refrigerated: 12 days
Frozen -20°: 30 days
Frozen -70°: 90 days
Refrigerated: 12 days
Frozen -20°: 30 days
Frozen -70°: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Acidified urine
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
P.M. Sets up 2 days a week.
Reference Range
| Methylmalonic Acid, Urine | 0.3-2.2 mmol/mol creat |
Creatinine, Random Urine
| 0-6 Months | 0.18-2.48 mmol/L |
| 7-11 Months | 0.18-2.74 mmol/L |
| 1-2 Years | 0.18-9.72 mmol/L |
| 3-8 Years | 0.18-11.49 mmol/L |
| 9-12 Years | 0.18-14.14 mmol/L |
| >12 Years | 1.77-23.31 mmol/L |
Clinical Significance
Methylmalonic Acid (MMA) is useful to diagnose and monitor Vitamin B12 (cobalamin) deficiency, and to diagnose and monitor patients with methylmalonic acidemia.
Last Updated: September 24, 2014
