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Alkaline Phosphatase, Bone Specific
MessageThis test is currently only available in Bedford CPRS. If you are a BHS provider and wish to see this test offered in BHS CPRS- please contact the BHS Laboratory.
Testing performed at Quest Diagnostics.
Testing performed at Quest Diagnostics.
Test Code
ALK PHOS, BONE(O)
CPT Codes
84075
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 21 days
Refrigerated: 7 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Non-serum samples • Grossly icteric
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues-Sat; Report available: 1-2 days
Reference Range
| Adult Male | |
| 18-29 years | 8.4-29.3 mcg/L |
| 30-39 years | 7.7-21.3 mcg/L |
| 40-49 years | 7.0-18.3 mcg/L |
| 50-68 years | 7.6-14.9 mcg/L |
| >68 years | Not established |
| Adult Female | |
| 18-29 years | 4.7-17.8 mcg/L |
| 30-39 years | 5.3-19.5 mcg/L |
| 40-49 years | 5.0-18.8 mcg/L |
| 50-76 years | 5.6-29.0 mcg/L |
| >76 years | Not established |
| Premenopausal | |
| 35-45 years | 5.0-18.2 mcg/L |
| Pediatric | Male (mcg/L) | Female (mcg/L) |
| 2-24 months** | 25.4-124.0 | 25.4-124.0 |
| 25 months-5 years | Not established | Not established |
| 6-9 years | 41.0-134.6 | 41.0-134.6 |
| 10-13 years | 43.8-177.4 | 24.2-154.2 |
| 14-17 years | 13.7-128.0 | 10.5-75.2 |
Clinical Significance
The bone-specific alkaline phosphatase (BSAP) assay provides a general index of bone formation and a specific index of total osteoblast activity. BSAP and osteocalcin are the most effective markers of bone formation and are particularly useful for monitoring bone formation therapies and antiresorptive therapies.
Last Updated: September 6, 2014
