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BK Virus DNA, Quantitative, Real-Time PCR, Urine
MessageThis test is currently only available in BHS CPRS. If you are a Bedford provider and wish to see this test offered in Bedford CPRS- please contact the Bedford Laboratory.
Testing performed at Quest Diagnostics.
Testing performed at Quest Diagnostics.
Test Code
BK VIRUS, URINE(O)
CPT Codes
87799
Preferred Specimen
4.3 mL random urine submitted in a cobas® PCR Media tube
Minimum Volume
4.3 mL
Instructions
Neat urine must be immediately stabilized by transferring to a cobas® PCR Media tube.
Liquid level must be between the black fill lines on the cobas® PCR Media tube label window.
Liquid level must be between the black fill lines on the cobas® PCR Media tube label window.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 90 days
Refrigerated: 90 days
Frozen: Unacceptable
Refrigerated: 90 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Under-or over-filled cobas® PCR urine sample tubes • Neat urine
Methodology
Real-Time Polymerase Chain Reaction
Setup Schedule
Set up: Daily; Report available: 1 day
Reference Range
| BK Virus DNA, QN PCR | Not Detected (IU/mL) |
| BK Virus DNA, QN PCR | Not Detected (Log IU/mL) |
Clinical Significance
This test detects and quantitates BK Virus DNA in urine specimens of kidney transplant recipients who are at risk of developing BKV-associated nephropathy (BKVAN) and associated hemorrhagic cystitis leading to kidney failure. Prospective viral load monitoring of BKV DNA in urine (and plasma) is useful to exclude a diagnosis of BKVAN and to monitor the course of BKV infection. The assay is calibrated to the First World Health Organization International Standard for BKV DNA with a Reportable Range of 200-100,000,000 IU/mL (2.30-8.00 log IU/mL).
Last Updated: September 6, 2014
