HAYSTACK MRD MONITORING(O)

HAYSTACK MRD MONITORING(O)

30 mL whole blood collected in 3 Streck cell-free (black/tan tiger-top) glass tubes

24 mL

Sample collection using a straight needle is preferred. Use Streck tubes only. All tubes must be filled completely. Gently invert tube at least 8 times immediately after draw.

Please note: If Hospital Discharge Date is not populated, outpatient treatment is assumed.

Cell-free DNA Streck tube

Room temperature

Room temperature: 7 days
Refrigerated: Unacceptable
Frozen: Unacceptable

Hemolysis

Daily

7-14 days

Haystack MRD™ Monitoring - Haystack MRD™ is a tumor-informed minimal residual disease (MRD) test that analyzes circulating tumor DNA (ctDNA) in the blood of patients who have been diagnosed with cancer or a previous diagnosis of cancer. The test requires identification of tumor-specific mutations for the development of a personalized ctDNA assay (Haystack MRD™ Personalization). The personalized assay is used to measure ctDNA to identify the presence of cancer in an initial blood sample (Haystack MRD™ Baseline) and at subsequent timepoints (Haystack MRD™ Monitoring).

Circulating tumor DNA (ctDNA) in blood is measured at specified intervals, after baseline, using the tumor- specific, personalized assay developed in the previous Haystack MRD™ Personalization step. Detection of ctDNA at one or multiple timepoint(s) may inform a patient's response to therapy and/or indicate cancer recurrence.