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CLOZAPINE
Test CodeCLOZAPINE(BHS)
Preferred Specimen
Serum-Plain Red
Minimum Volume
200 uL
Instructions
Do Not Use Serum Separator Tubes. Trough samples (12 hours after the last dose) at steady state (3 days after a dose change) are recommended for testing. Prepare serum within 2 hours of blood collection.
Transport Temperature
Refrigerated
Specimen Stability
Serum samples may be stored at room temperature or 2 to 8°C for up to 7 days before testing.
Methodology
Homogenous two reagent nanoparticle agglutination assay
Setup Schedule
Daily
Report Available
In less than 2 days
Limitations
As with any assay utilizing mouse antibodies, the possibility exists for interference by human anti-mouse antibodies (HAMA) in the sample. Samples containing such antibodies can potentially produce erroneous clozapine results, which are inconsistent with the patient’s clinical profile.
Reference Range
350-600 ng/mL
Clinical Significance
Clozapine 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo [b,e] [1,4] diazepine is a tricyclic dibenzodiazepine derivative atypical antipsychotic agent used for treatment resistant schizophrenia and reducing suicidal behavior in schizophrenia and schizoaffective disorder.
Performing Laboratory
West Roxbury Chemistry
Jonathan Dryjowicz-Burek
857-203-5418
Jonathan Dryjowicz-Burek
857-203-5418
Last Updated: January 7, 2025
