Measles Antibody (IgM)

Test Code

34256

CPT Codes
86765<br>This test is not available for New York patient testing. For New York patients, please use test code 901434

Preferred Specimen

1 mL serum

Minimum Volume

0.2 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Methodology
Immunofluorescence Assay (IFA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon, Tues, Thurs-Sat; Report available: 1-3 days

Reference Range

Titer	Interpretation
<1:20	Antibody not detected
≥1:20	Antibody detected

The traditional serologic diagnosis of measles requires a significant rise in antibody titer between acute and convalescent sera. However, detection of IgM antibody in a single specimen may indicate acute disease.
Correct interpretation of serologic data depends upon the proper timing of specimen collection in relation to rash onset. This timing is particularly important for interpreting negative IgM results, since IgM antibody peaks approximately 10 days after rash onset and is usually undetectable 30 days after rash onset.

Clinical Significance

Measles, also known as Rubeola, causes fever, irritability, respiratory illness, and the characteristic skin rash. Immunization has greatly diminished the incidence of measles. The presence of IgG is consistent with immunity or prior exposure. IgM is consistent with current or recent infection. IgM tests can generate false positive results and low levels of IgM can persist for longer than 12 months.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.