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Fungitell (1-3) B-D-Glucan Assay
Test CodeFUNG
Quest Code
16283
CPT Codes
87449
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
Draw blood in plain red-top tube or serum separator tube, spin down, then aliquot off into a cryogenic vial (DNAse, RNAse, pyrogen-free). Glucan free tubes are acceptable.
Transport Container
Cryogenic vial (DNAse, RNAse, pyrogen-free)
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 5 days
Frozen: 14 days
Refrigerated: 5 days
Frozen: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Lipemia • Icteric • Turbid serum • Specimens other than serum • Glass tubes
Methodology
Protease Zymogen-based Colorimetric
Setup Schedule
Set up: Daily; Report available: 1-2 days
Reference Range
<60 pg/mL
Clinical Significance
Invasive Fungal Infections (IFI) are increasing, especially among immunocompromised patients. Most pathogenic fungi have (1-3)-beta-D-glucan in their cell walls and minute quantities are sloughed into the bloodstream and appear in the serum in cases of IFI. Monitoring serum (1-3)-beta-D-glucan for evidence of elevated and rising levels provides a convenient surrogate marker for IFI.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153