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Beta-Globin Complete
MessageCan be ordered as a reflex test for the Hemoglobinopathy Evaluation (Order Code HE).
Test Code
BGL
Alias/See Also
Beta-Thalassemia Mutation Analysis
Quest Code
14974
Quest Code
14974
CPT Codes
81404
Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
3 mL
Other Acceptable Specimens
5 mL whole blood collected in an ACD solution A or B (yellow-top) tube
5 mL whole blood collected in a sodium heparin (green-top) tube
5 mL whole blood collected in a sodium heparin (green-top) tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 8 days
Refrigerated: 8 days
Frozen: unacceptable
Refrigerated: 8 days
Frozen: unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen
Methodology
DNA Sequencing
Polymerase Chain Reaction (PCR)
This test was developed and its performance characteristics have been determined by Quest Diagnostics. Performance characteristics refer to the analytical performance of the test.
Setup Schedule
Monday, Thursday a.m.
Report Available
16 days
Limitations
If these mutations are not found by the testing procedure, it does not mean that the risk of carrying or developing beta thalassemia is not present. It simply means that these specific mutations have not been found with this assay, although other mutations may be present.
Clinical Significance
1) To identify disease-causing mutations in individuals affected with beta-thalassemia.
2) To identify carriers in high-risk ethnic group or people with positive family history.
3) Prenatal diagnosis of beta-thalassemia.
2) To identify carriers in high-risk ethnic group or people with positive family history.
3) Prenatal diagnosis of beta-thalassemia.
Performing Laboratory
Quest Diagnostics Nichols Institute
San Juan Capistrano, CA
