Hepatitis E Virus Antibodies (IgG/IgM)

Test Code

HEAB

Alias/See Also

Anti-HEV
Anti-Hepatitis E (IgG, IgM)

Quest Code
15085

CPT Codes
86790 (x2)

Preferred Specimen

1 mL serum collected in a no additive (red-top) tube, transferred to a plastic screw-cap vial

Minimum Volume

0.2 mL

Transport Temperature

Refrigerated

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Methodology
Enzyme Linked Immunosorbent Assay (ELISA)

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Tuesday, Friday a.m.

Report Available

2-5 days

Clinical Significance

Hepatitis E virus (HEV) is the major etiologic agent of enterically transmiited non-A, non-B hepatitis worldwide and has a high case-fatality rate in pregnant women. Both IgM and IgG antibody to HEV (anti-HEV) are produced following infection. The titer of IgM anti-HEV declines rapidly during early convalescence; IgG anti-HEV persists and appears to provide at least short-term protection against disease. Both HEV IgM and IgG are typically detected within one month after infection; IgM persists for about two months, whereas IgG levels persist for months to years after recovery. Approximately 20% of the U.S. population is positive for HEV IgG, indicating that HEV exposure is more common than previously thought.

Performing Laboratory
Focus Diagnostics, Inc.
San Juan Capistrano, CA

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.