A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Metanephrines, Plasma
Test CodePMET
Alias/See Also
Metanephrines, Fractionated, Free, LC/MS/MS, Plasma
Quest Code
19548
Quest Code
19548
CPT Codes
83835
Includes
Metanephrine
Normetanephrine
Total Metanephrine
Normetanephrine
Total Metanephrine
Preferred Specimen
2.5 mL plasma collected in an EDTA (lavender-top) tube, transferred to a plastic screw-cap vial
Minimum Volume
1.5 mL plasma
Patient Preparation
Overnight fasting is preferred.
Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise before collection.
Patient Preparation
Overnight fasting is preferred.
Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise before collection.
Instructions
Draw specimen in two pre-chilled EDTA (lavender-top) tubes. The whole blood sample should be kept on wet ice until centrifuged. Separate the plasma within 2 hours of venipuncture. After centrifugation, the plasma should immediately be transferred to a plastic, leak-proof vial. Refrigerate.
Transport Temperature
Refrigerated
Specimen Stability
Room temperature: 4 hours
Refrigerated: 14 days
Frozen: 14 days
Refrigerated: 14 days
Frozen: 14 days
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Setup Schedule
Monday-Saturday a.m.
Report Available
2 days
Limitations
False-positive results have been observed in patients with either chronic kidney disease or hypertension.
Clinical Significance
Normetanephrine (NM) and metanephrine (MN) are the extra-neuronal catechol-o-methyl transferase (COMT) metabolites of the catecholamines norepinephrine and epinephrine, respectively. Measurement of plasma metanephrines is more sensitive (but may be less specific) than measurement of catecholamines for the detection of pheochromocytoma. Proper interpretation of results requires awareness of recent medication/drug history (e.g., antihypersensitive agents, alcohol, cocaine) and other pre-analytical factors (e.g., stress, severe congestive heart failure, myocardial infarction) that influence release of catecholamines and metanephrines.
Performing Laboratory
Quest Diagnostics Nichols Institute
Chantilly, VA
Performing Laboratory
Quest Diagnostics Nichols Institute
Chantilly, VA