Sirolimus (Rapamycin) (RAPAMY)

Message

Optimal time to draw specimen: 1 hr before next oral dose (12 hour trough).

Test Code

LAB875

Quest Code

36712

CPT Codes
80195

Preferred Specimen

2 mL whole blood collected in an EDTA (lavender-top) tube

Patient Preparation
Collect specimen 1 hour prior to next dose (12 hour trough)

Minimum Volume

1 mL

Instructions

Draw 2-3 mL of whole blood into lavender-top tube. Ship and store refrigerated. Shipping at ambient temperature (<25 C) is acceptable.

Transport Container

Preferred: Lavender top tube; Acceptable: Sodium heparin green top tube; Tan top tube (lead-free)

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Clotted specimen

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Monday-saturday

Reference Range

3.0-18.0 ng/mL

Clinical Significance

Sirolimus is an immunosuppressant drug used to prevent organ graft rejection. Therapeutic drug monitoring is used to optimize dose and avoid toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is approximately 72 hours; in females approximately 61 hours.

Performing Laboratory

Quest Diagnostics Nichols Institute-Chantilly VA

14225 Newbrook Drive

Chantilly, VA 20151-2228

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.